Objective: To Study the Efficacy of Screening Panel, Including Interleukin 6, in Diagnosis of Neonatal Sepsis. Materials and Methods: This prospective study was done from 2015-2016 in the Post Graduate department of Pediatrics of Subharti Medical College, Meerut. 100 neonates below the age of 28 days with a clinical suspicion of neonatal sepsis were enrolled in the study. Septic panel (WBC, ANC, I/T ratio, Micro ESR, CRP), IL-6 and blood culture were sent for screening. Data was collected and

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... alyzed in babies having a positive blood culture. Septic panel in blood culture positive babies with >3variables of septic panel without IL-6, were compared with septic panel in blood culture positive babies with > 3 variables of septic panel with IL-6. Data was analyzed. Result: Presence of the new marker (IL-6) with the septic panel shows a sensitivity of 65.71%, specificity of 96.92% and PPV of 92.0% against the septic panel without IL-6, which shows a sensitivity of 34.28%, specificity of 93.84% and PPV of 75.0%. Conclusion: Septic panel with IL-6 has more sensitivity, specificity and positive predictive value as compared to septic panel without IL-6.