Long term heart preservation is one of the most important problems for clinical heart transplantation. We use the continuous hypothermic coronary perfusion method for experimental trial. In this experiment two kinds of perfusates were examined for 24 h heart preservation. One is modified Collins' (MC) solution (group A) and the other is perfluorochemicals (PFC) added MC solution (group B). The change in heart weight was less in group B than in group A. Perfusion flow was very unstable in group

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... . Left ventricular passive compliance was markedly depressed in group A than in group B. The concentration of CPK, LDH in perfusate was higher in group A than in group B. These data indicate that group B is preserved in better conditions than group A and perfluorochemicals has good effects for long term heart preservation.