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An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization
[article]
2020
bioRxiv
pre-print
Intron retention is known to regulate gene expression. We recently described intron retention as the predominant splicing programme characterizing early stages of motor neurogenesis from human induced pluripotent stem cells (hiPSCs) and it's perturbation in familial amyotrophic lateral sclerosis (ALS). Here, we sought to gain more insight into the nucleocytoplasmic distribution of aberrant intron-retaining transcripts (IRTs) and to identify their discriminating molecular features. We combined
doi:10.1101/2020.07.20.211557
fatcat:ffnryrj5vveutbp5fxvqcgxk4m