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Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle
American Journal of Physiology - Cell Physiology
Yamamura H, Cole WC, Kita S, Hotta S, Murata H, Suzuki Y, Ohya S, Iwamoto T, Imaizumi Y. Overactive bladder mediated by accelerated Ca 2ϩ influx mode of Na ϩ /Ca 2ϩ exchanger in smooth muscle. The Na ϩ / Ca 2ϩ exchanger (NCX) is thought to be a key molecule in the regulation of cytosolic Ca 2ϩ dynamics. The relative importance of the two Ca 2ϩ transport modes of NCX activity leading to Ca 2ϩ efflux (forward) and influx (reverse) in smooth muscle, however, remains unclear. Unexpectedly,doi:10.1152/ajpcell.00065.2013 pmid:23703524 fatcat:bitq3ufz6jdodjaq4iafuidv3q