clear that monsters are not due to germinal and heredi¬ tary causes, but are products from normal embryos by influences which are to be sought in their environ¬ ment" be applicable here. More to the point is the term, used by many, "cytoplasmic variation," in which it is suggested that in the germ cell there is a predilection for the ultimate form of the body, which at least influ¬ ences these malformations. The expression leaves the problem practically untouched, except that it tranfers its

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... sideration to an early period in development. The present case offers proof, as instanced by the reversed anomalous aortic branches, the primitive heart, the reversed root of the lungs and azygos veins, the rela¬ tionship of the pancreas and the unrotated intestines, that these anomalies have their causative factor operat¬ ing at a very early embryonic period. Note.-The specimen is the property of the department of anatomy of the University of Chicago, where it remains and may be seen.