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EVIDENCE FOR SEQUENCE-INDEPENDENT EVOLUTIONARY TRACES IN GENOMICS DATA
2001
Biocomputing 2002
Sequence conservation during evolution is the foundation for the functional classification of the ennormous number of new protein sequences being discovered in the current era of genome sequencing. Conventional methods to detect homologous proteins are not always able to distinguish between true homologs and false positive hits in the twilight zone of sequence similarity. Several different approaches have been proposed to improve the sensitivity of these methods. Among the most successful are
doi:10.1142/9789812799623_0023
fatcat:e4uesxuyjzgzhgje6rjnnnt3f4