Endoplasmic Reticulum Stress in Reproductive Function

Kang-sheng LIU, Yu ZENG, Hang-peng ZHENG, Ya-jun CHEN
2016 Journal of International Translational Medicine  
Normal folding requires that unique conditions should be maintained within the endoplasmic reticulum (ER) lumen, and nascent proteins are initially bound to Ca2+dependent chaperone proteins. Proteins synthesized in the ER are properly folded with the assistance of ER chaperones. misfolded proteins are disposed by ER-associated protein degradation. Accumulation of misfolded proteins in the ER triggers an adaptive ER stress response, which leads to activation of the unfolded protein response
more » ... , a conserved pathway that transmits signals to restore homeostasis or eliminate the irreparably damaged cells. It has been shown that ER stress involves in pathophysiological development of many diseases, including neurological diseases. However, nowadays, a few studies have begun to focus on the possibility that the accumulation of misfolded proteins can also contribute to reproductive diseases. In this article, we mainly introduced the involvement of ER stress response in preimplantation embryos, placental development, intrauterine growth restriction (IUGR) and testicular germ cells so as to provide important insights for the molecular mechanisms of ER stress-induced apoptosis in reproductive diseases.
doi:10.11910/2227-6394.2016.04.03.02 doaj:1730d5983abb4eeb9b89e62003a63b4f fatcat:kjuwyddhhngddohc7ifjr4ali4