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Endoplasmic Reticulum Stress in Reproductive Function
Journal of International Translational Medicine
Normal folding requires that unique conditions should be maintained within the endoplasmic reticulum (ER) lumen, and nascent proteins are initially bound to Ca2+dependent chaperone proteins. Proteins synthesized in the ER are properly folded with the assistance of ER chaperones. misfolded proteins are disposed by ER-associated protein degradation. Accumulation of misfolded proteins in the ER triggers an adaptive ER stress response, which leads to activation of the unfolded protein responsedoi:10.11910/2227-6394.2016.04.03.02 doaj:1730d5983abb4eeb9b89e62003a63b4f fatcat:kjuwyddhhngddohc7ifjr4ali4