Cytokine activity after human bone marrow transplantation. Production of interferons by peripheral blood mononuclear cells from recipients of HLA-identical sibling bone marrow transplants

M A Cooley
1987 Journal of Immunology  
Peripheral blood mononuclear cells (PBMC) from 43 recipients of HLA-identical sibling bone marrow transplants were tested for their capacity to produce IFN after stimulation in vitro with PHA. Total IFN production, as measured in a bioassay, and production of IFN-gamma, measured by radioimmunoassay, was within or above the normal range (mean production by PBMC from normal persons +/- 2 SD) for 29 of 39 and 31 of 43 recipients, respectively. Production did not correlate with time after
more » ... , or with the presence or type of immunosuppressive chemotherapy used, although there was a tendency for lower production in recipients with chronic graft-vs-host disease. This near normal production of IFN contrasts with our previous observation that IL 2 production in bone marrow transplant recipients is severely impaired for at least 6 mo post-transplant.
doi:10.4049/jimmunol.138.11.3742 fatcat:gkc3hpwsgbc5pifizmrqph6ici