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Anti-glomerular basement membrane nephritis and Goodpasture syndrome result from autoantibody (Ab)-mediated destruction of kidney and lung. Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, but little is known about Ab origins or structure. This ignorance is due in part to the inability to recover monoclonal Ab by transformation of patients' blood cells. The aim of this study was to assess the suitability of two humanized models for this purpose. Methods: NOD-scid-gammadoi:10.1186/s12967-015-0539-4 pmid:26048777 pmcid:PMC4467618 fatcat:p2wyhhw3r5gdro4tbyhjqbbv6y