Role of Gadd45 Protein Family in Tumorigenesis and Development

CAO Yu, NI Juan, CAO Neng, YANG Guofang, XUE Jinglun, WANG Xu
2019 Zhongliu Fangzhi Yanjiu  
Gadd45 protein is a stress protein that responds to the environment and plays an important role in the regulation of various cell functions such as DNA repair, cell cycle and senescence and genotoxic stress. These proteins include three subtypes: α, β and γ. A large number of studies have shown that they are involved in the regulation of various signaling pathways in tumor cells, which are closely related to the occurrence and development of tumors, and their expression are closely related to
more » ... mor prognosis. In this paper, we briefly introduce and elaborate the research progress of Gadd45 protein family in tumor development in recent years.
doi:10.3971/j.issn.1000-8578.2019.18.1517 doaj:9e5769eb29594af1aceb1959de64bebb fatcat:sfkrhfn42rcpdhj2zxdubiolba