Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Ayman M. F. Elgohary
2013 Science Journal of Chemistry  
A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were synthesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c displayed the highest activity among the
more » ... ctivity among the test compounds with IC50 < 5 mg/mL
doi:10.11648/j.sjc.20130101.11 fatcat:5gnqnu7bxvf3pp5lnpwtk5xjme