T-cell receptor excision circles (TREC) and maintenance of long-term non-progression status in HIV-1 infection

Max W Richardson, Andrij E Sverstiuk, Edward J Gracely, Houria Hendel, Kamel Khalili, Jean-François Zagury, Jay Rappaport
2003 AIDS (London)  
T-cell receptor excision circles (TREC) in peripheral blood mononuclear cells (PBMC) were evaluated in the Genetic Resistance to Human Immunodeficiency Virus cohort of HIV-1-seropositive non-progressors (NP). After a short follow-up, NP were sub-grouped as stable (NP-S), or with signs of disease progression (NP-P). Initial TREC were higher in NP-S compared to NP-P ( P = 0.002), even after adjusting for CD4 and CD8 T-cell counts and viral load ( P = 0.048), but not p24 antigenemia ( P = 0.076).
more » ... emia ( P = 0.076). Higher initial TREC were 100% predictive of the maintenance of non-progression status during follow-up. The development of quantitative competitive polymerase chain reaction (QC-PCR) assays to detect episomes from T-cell receptor (TCR) gene rearrangement [ ] was originally described as a means of quantitating recent thymic emigrants [ ]. Reduced T-cell receptor excision circles (TREC) in HIV-1 infection and their rebound with highly active antiretroviral therapy [ ], however, reflect a balance between the production, proliferation, redistribution and elimination of circulating T cells that have recently undergone TCR rearrangement or few cell divisions since TCR rearrangement [ ]. The decrease in TREC in HIV-1-infected adults is now thought largely to reflect cellular proliferation and death caused by viral immune activation [ ]. It is also possible that reduced thymic output and increased proliferation are not mutually exclusive causes of the TREC decline in HIV infection [ ].
doi:10.1097/00002030-200304110-00018 pmid:12660540 fatcat:walxyfcrcrfwlcvyxcjzammkgq