A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2023; you can also visit the original URL.
The file type is application/pdf.
Helper T lymphocytes which recognize the MHC class I alloantigens in vivo are CD4+CD8-1
1988
Journal of Immunology
Preserved Fulltext
To determine the CD4 or CD8 phenotype of the Th lymphocyte which recognizes in vivo the MHC class I alloantigens, B10 recombinant mice were treated with anti-CD8 or anti-CD4 mAb and immunized with lymphoid cells from donors differing in the K or D region of the MHC. Alloantibodies were evaluated by a 51Cr-release assay or by indirect immunofluorescence. The production of IgG anti-Dd and anti-Kk alloantibodies was increased by the deletion of the CD8+ and absent in mice depleted of the CD4+
doi:10.4049/jimmunol.141.12.4129
fatcat:eihnepdnnrde7gu6xovahwnlje