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The use of genomics in microbial vaccine development
2009
Drug Discovery Today
Vaccination is one of the most effective tools for the prevention of infectious diseases. The availability of complete genome sequences, together with the progression of high-throughput technologies such as functional and structural genomics, has led to a new paradigm in vaccine development. Pan-genomic reverse vaccinology, with the comparison of sequence data from multiple isolates of the same species of a pathogen, increases the opportunity of the identification of novel vaccine candidates.
doi:10.1016/j.drudis.2008.12.007
pmid:19150507
pmcid:PMC7108364
fatcat:q2mrqum2enccthsgby42kxgj3q