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The article provides a brief literature review on the problem of asymptomatic pancreatic hyperenzymemia and an algorithm for examining patients. The authors for the first time in Ukraine have described the clinical observation of family with Gullo's syndrome — family benign pancreatic hyperenzymemia. Family members were carefully examined, structural changes in the pancreas were excluded, and its normal functional state was proved. The results of a genetic examination are presented.doi:10.33149/vkp.2017.04.08 fatcat:6ain6sqe4rfk7nfskmewn2mnfe