Some of the effects of Therapeutic, Acute, and Overdose treatment of Chloroquine, Artesunate, and Amodiaquine-Artesunate combined therapy on the Left ventricle and Ascending Aorta of Adult wistar rats were studied using biochemical estimation of activities of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase. The drugs were dissolved in distilled water and administered orally using an orogastric tube. The animals were sacrificed on days 1, 3, and 5 respectively after which the excised

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... tissues were subjected to biochemical analysis. The levels of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase in the Left ventricle and Ascending aorta was highest in the Overdose treatment groups showing statistically significant results (P< 0.05) following treatment with Chloroquine, Artesunate, and Amodiaquine-Artesunate combined therapy. There was also statistically significant alteration (P< 0.05) in their activities in the Left ventricle and ascending aorta, of the animals treated at Acute dose of the drugs. However, there was no statistically significant alteration (P< 0.05) in the levels of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase in the Left ventricle and ascending aorta of the animals treated with the Therapeutic dose of the drugs. The findings in this study suggests that Chloroquine, Artesunate and Amodiaquine -Artesunate combined therapy altered the enzymatic antioxidant defense system and elevated the levels of Lactate Dehydrogenase in the Left ventricle and Ascending Aorta of the Adult wistar rats.