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A B S T R A C T Hepatocellular carcinoma (HCC) is a major primary liver malignancy in adults. Despite the progress made, the outcome of the treatment to this disease is less than satisfactory as the post therapy tumor recurrence is almost inevitable. Accumulating pieces of evidence have suggested that the recurrence is due to the existence of a subpopulation of the HCC cells that possess the properties of stem cells and are resistant to radiation and chemotherapy. It is therefore important todoi:10.1016/j.canlet.2015.02.006 pmid:25676692 fatcat:nhdfxa2ka5egjhff7anlx6fjwa