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Single-sample SNP detection by empirical Bayes method using next-generation sequencing data
2015
Statistics and its Interface
The rapid development of next generation sequencing technology is changing the way of biological research in many aspects, which has become the most popular platform for the genomic structural variation detection. In this paper, we focus on the single-sample next generation sequencing data analysis, and propose a hierarchical structure to model the dispersion of minor allele frequency in the genome scale. The empirical Bayes method is employed to estimate the hyper-parameters, and the minor
doi:10.4310/sii.2015.v8.n4.a5
fatcat:emltc6z76nh23kn3hcmwucpdtq