Radiotoxicity of iodine-125-labeled oligodeoxyribonucleotides in mammalian cells

O A Sedelnikova, I G Panyutin, A R Thierry, R D Neumann
1998 Journal of Nuclear Medicine  
The dramatic difference in radiotoxicity between 125I-ODN and 125I-UdR confirms that, despite the nuclear localization, 125I-ODN are not bound to or incorporated within the genomic DNA. Our data demonstrate that the radiotoxicity of Auger electron emitters is determined by the radiation dose delivered to nuclear DNA, not necessarily to the nucleus. Therefore, relatively high intracellular concentrations of unbound 125I-ODN can be achieved without causing significant cell death.
pmid:9708519 fatcat:kmkn4bhkgnhgbgllccqku3p4vm