Association of interferon-γ inducible protein-10 pretreatment level and sustained virological response in HCV-positive Egyptian patients

Dalia Omran, Sherif Hamdy, Salwa Tawfik, Serag Esmat, Doa'a A Saleh, Rania A Zayed
2014 Annals of Clinical and Laboratory Science  
The response to antiviral therapy in HCV infected patients depends on several predictive factors; however, the ability to achieve sustained virological response is still limited to around 60% of the patients infected with the HCV-4 genotype. Increased serum and intrahepatic interferon -γ inducible protein 10 (IP-10) levels in patients with chronic hepatitis C have been described. The aim of the work was to study the impact of pretreatment serum IP-10 level on the antiviral treatment outcome in
more » ... eatment outcome in a group of Egyptian patients infected with HCV. The study included 80 treatment naive HCV patients. Serum IP-10 levels were determined by an enzyme linked immunosorbent assay before therapy was introduced. Serum samples were examined twice by Real-Time PCR after complete course of therapy for detection of HCV RNA; at the end of the antiviral therapy and six months later to detect sustained virological response (SVR). 57 patients (71%) achieved SVR while 23 (29%) patients were non-responders (NR). Pretreatment serum IP-10 levels were significantly lower in patients who achieved SVR than in NR (p=0.000). Low pretreatment serum IP-10 is a favorable predictive of response to antiviral HCV therapy in Egyptian patients.
pmid:24795055 fatcat:v44gtcymbjfsdd7ns6zonk6kt4