Developmental tumours, early differentiation and the transforming growth factor beta superfamily

C L Mummery, A J van den Eijnden-van Raaij
1999 International Journal of Developmental Biology  
Embryonal carcinoma and embryonic stem cells have been very useful models for identifying some of the factors that regulate differentiation in early mammalian development. Here, we present a brief history of their original isolation and characterization and of their later introduction into the Hubrecht Laboratory. We illustrate in a review their contribution to our current understanding of the function of transforming growth factor beta and ligands binding to the receptors of a related factor,
more » ... a related factor, activin, in development with some of our own work.
pmid:10668979 fatcat:ey6rokihgvf63b2mtxvui7vf34