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Identification of Residues in α-Macroglobulins Important for Binding to the α2-Macroglobulin Receptor/Low Density Lipoprotein Receptor-related Protein
1996
Journal of Biological Chemistry
Preserved Fulltext
Variants of the receptor binding domain of both human ␣ 2 -macroglobulin and the corresponding domain of hen egg white ovomacroglobulin have been expressed in Escherichia coli and refolded in vitro. Competition experiments with methylamine-treated ␣ 2 -macroglobulin for binding to the multifunctional ␣ 2 -macroglobulin receptor identify two Lys residues (residues 1370 and 1374 in human ␣ 2 -macroglobulin) spaced by three amino acid residues as crucial for receptor binding. From this result and
doi:10.1074/jbc.271.22.12909
pmid:8662686
fatcat:iui5ahdrcfd77i2wosqgh3wvvq