Cooling in industrial production and refrigeration of perishable and nonperishable products is common practice throughout the world. Research studies have been conducted both experimentally and numerically to simulate Vapor Compression Refrigeration System (VCRS) and its performance respectively, however, experimental procedure often seems to be expensive and time-consuming to carry out due to the function of many variables. This study was therefore designed to numerically simulate the

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... ce assessment of a nanoparticle enhanced VCRS. A numerical model of a vapor compression refrigeration system was developed using standard refrigeration equations on each of the major components of the refrigeration system such as compressor, evaporator, condenser and expansion valve. The model was then simulated on a MATLAB platform with a CoolProp installed packages via Python under two different simulation cases. In the first case, the mass fractions were varied for CuO, TiO 2 and Al 2 O 3 nanoparticles while their densities remained constant and a reversed condition was investigated for the second case. The results showed that both the refrigerating effect and the Coefficient Of Performance (COP) of the system increase as both the mass fraction and density of all the nanoparticles increases. It also shows that the compressor work decreases as both the mass fraction and density of all the nanoparticles were increased. On comparing the computational and numerical analysis results, the study established no significant difference in terms of COP and the use of nanoparticles were found to have improved the COP of the system.