A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study

Jennifer D Brooks, John D Boice, Roy E Shore, Anne S Reiner, Susan A Smith, Leslie Bernstein, Julia A Knight, Charles F Lynch, Esther M John, Kathleen E Malone, Lene Mellemkjaer, Rikke Langballe (+7 others)
Objective: To examined the impact of reproductive factors on the relationship between radiation treatment (RT) for a first breast cancer and risk of contralateral breast cancer (CBC). Methods: The Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based case-control study where cases are women with asynchronous CBC (N ¼ 1521) and controls are women with unilateral breast cancer (N ¼ 2211). Rate ratios (RR) and 95% confidence intervals (CI) were
more » ... timated using conditional logistic regression to assess the independent and joint effects of RT (ever/never and location-specific stray radiation dose to the contralateral breast [0, >0-<1Gy, 1Gy]) and reproductive factors (e.g., parity). Results: Nulliparous women treated with RT (1Gy dose) were at increased risk of CBC compared with nulliparous women not treated with RT, although this relationship did not reach statistical significance BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ ). The Breast 54 (2020) 62e69 Contralateral breast cancer WECARE Study (RR ¼ 1.34, 95% CI 0.87, 2.07). Women treated with RT who had an interval pregnancy (i.e., pregnancy after first diagnosis and before second diagnosis [in cases]/reference date [in controls]) had an increased risk of CBC compared with those who had an interval pregnancy with no RT (RR ¼ 4.60, 95% CI 1. 16, 18.28). This was most apparent for women with higher radiation doses to the contralateral breast. Conclusion: Among young female survivors of breast cancer, we found some evidence suggesting that having an interval pregnancy could increase a woman's risk of CBC following RT for a first breast cancer. While sampling variability precludes strong interpretations, these findings suggest a role for pregnancy and hormonal factors in radiation-associated CBC.
doi:10.17863/cam.58981 fatcat:iiik4juujfao7mv7voc7sl6pt4