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Genetic variation in surfactant protein-A2 alters responses to ozone
2021
PLoS ONE
Increased exposure to Ozone (O3) is associated with adverse health effects in individuals afflicted with respiratory diseases. Surfactant protein-A (SP-A), encoded by SP-A1 and SP-A2, is the largest protein component in pulmonary surfactant and is functionally impaired by O3-oxidation. We used humanized SP-A2 transgenic mice with allelic variation corresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 in the lectin domain to determine the impact of this genetic
doi:10.1371/journal.pone.0247504
pmid:33617569
pmcid:PMC7899376
fatcat:zz7z4ecjr5darnmk7355pcke2e