The Review of Clear Cell Type of Epithelial Ovarian Cancers

Cosan Terek, Yilmaz Dikmen, Volkan Turan, Aydin Ozsaran, Osman Zekioglu, Necmettin Ozdemir
2012 Journal of Turkish Society of Obstetric and Gynecology  
ÖZET Amaç: Berrak hücreli tip epitelyal over kanserlerinin özellikleri, klinik yaklafl›m ve sa¤kal›mlar›n›n incelenmesi Gereç ve yöntemler: Ege Üniversitesi T›p Fakültesi Kad›n Hastal›klar› ve Do¤um Anabilim dal›nda Ocak 1994 ile Eylül 2007 tarihleri aras›nda histopatolojik olarak berrak hücreli tip epitelyal over kanseri tan›s› konmufl 63 hasta çal›flmaya al›nd›. Hastalar›n yafllar›, tan› an›ndaki evreleri, cerrahi ifllem sonras› histopatolojik tan›lar› ve sa¤kal›m süreleri incelendi. Eksiksiz
more » ... verilere toplam 18 hastada ulafl›labilmifltir. Bulgular: Otuz iki hastada saf berrak hücreli karsinom (12'si çift tarafl›), 12 hastada berrak hücreli ve endometrioid, 2 hastada berrak hücreli ve musinöz, 11 hastada berrak hücreli ve seröz (2 hastada çift tarafl›) bulundu. Alt› hastada ise hem seröz hem berrak hem de endometrioid tip bileflen birlikte bulundu. Eksiksiz olarak verilerine ulafl›labilen 18 hastan›n yafl ortalamas› 55,5 y›l olarak saptand›. Hastalar›n 10'u cerrahi evrelemeye göre evre I' de tan› al›rken di¤er 8 hasta evre 3 olarak saptand›. Hastalar›n hepsi cerrahi ifllem sonras›nda kemoterapi ald›lar. Hastalar 5 y›l içinde evrelerine göre incelendi¤inde Evre 1 için %60'› cerrahi ifllem sonras›nda sa¤ iken, evre 3 için bu oran %12,5 olarak bulundu. Sonuç: Erken evre berrak hücreli tip epitelyal over kanserleri di¤er erken evre epitelyal kanserlerle benzer sa¤kal›ma sahip olmalar›na ra¤men, ileri evrelerde daha kötü sa¤kal›m ortaya ç›kar. Anahtar kelimeler: berrak hücre over kanseri, kemoterapi Türk Jinekoloji ve Obstetrik Derne¤i Dergisi, (J Turk Soc Obstet Gynecol), 2012; Cilt: 9, Say›: 3, Sayfa: 129-32 SUMMARY THE REVIEW OF CLEAR CELL TYPE OF EPITHELIAL OVARIAN CANCERS Objective: To review the characteristics, clinical management and survival of clear cell type of epithelial ovarian cancers Material and methods: Between January 1994 and September 2007, 63 patients diagnosed with clear cell type epithelial overian cancer in department of obstetrics and gynecology Ege University Faculty of Medicine was included in the study. The age of the patients, surgical stage at the time of diagnosis, histopathological diagnosis after and the survival of the patients were reviewed. Complete data was present for 18 cases. Results: Thirty-two patients had pure clear cell carcinoma (12 of them bilateral), clear cell and endometrioid in 12 cases, clear cell and mucinous in 2 cases, clear cell and serous in 11 cases (2 of them bilateral). In 6 patients clear cell, serous and endometriod types existed together. The mean age of the 18 patients with complete data was 55.5 years. Ten patients were at stage 1 after surgical staging while 8 patients stage 3. All the patients received chemotherapy after the surgery. When the patients were evaluated by the stage, 60% of stage 1 patients and 12.5% of stage 3 patients were alive at the end of 5 years. Conclusion: Early stage clear cell type epithelial ovarian cancers have the same survival like other epithelial ovarian cancer types, worse survival rates are seen in advanced stages.
doi:10.5505/tjod.2012.34392 fatcat:eft4k2lvbjarxihczdnisnkywa