Recently, Big Data applications have rapidly expanded into different industries. Healthcare is also one the industries willing to use big data platforms so that some big data analytics tools have been adopted in this field to some extent. Medical imaging which is a pillar in diagnostic healthcare deals with high volume of data collection and processing. A huge amount of 3D and 4D images are acquired in different forms and resolutions using a variety of medical imaging modalities. Preprocessing

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... nd analyzing imaging data is currently a long process and cost and time consuming. However, not many big data platforms have been provided or redesigned for medical imaging purposes because of some restrictions such as data format. In this paper, we designed, developed and successfully tested a new pipeline for medical imaging data (especially functional magnetic resonance imaging - fMRI) using Big Data Spark / PySpark platform on a single node which allows us to read and load imaging data, convert them to Resilient Distributed Datasets in order manipulate and perform in-memory data processing in parallel and convert final results to imaging format while the pipeline provides an option to store the results in other formats such as data frame. Using this new solution and pipeline, we repeated our previous works in which we extracted brain networks from fMRI data using template matching and sum of squared differences (SSD) method. The final results revealed our Spark (PySpark) based solution improved the performance (in terms of processing time) around 4 times on a single compared to the previous work developed in Python.