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a report of t 4 -the transatlantic think tank for toxicology, a collaboration of the toxicologically oriented chairs in Baltimore, Konstanz and Utrecht sponsored by the Doerenkamp-Zbinden Foundation; participants do not represent their institutions and do not necessarily endorse all recommendations made. chapters give a historical background, illustrate the large variety of approaches, and highlight up-and downsides as well as specific requirements. Moreover, they refer to the application indoi:10.14573/altex1406111 fatcat:h2373gjoirg6hj2qv556jlliya