State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Natalie Alépée
2014 ALTEX: Alternatives to Animal Experimentation  
a report of t 4 -the transatlantic think tank for toxicology, a collaboration of the toxicologically oriented chairs in Baltimore, Konstanz and Utrecht sponsored by the Doerenkamp-Zbinden Foundation; participants do not represent their institutions and do not necessarily endorse all recommendations made. chapters give a historical background, illustrate the large variety of approaches, and highlight up-and downsides as well as specific requirements. Moreover, they refer to the application in
more » ... ease modeling, drug discovery and safety assessment. Finally, consensus recommendations indicate a roadmap for the successful implementation of 3D models in routine screening. It is expected that the use of such models will accelerate progress by reducing error rates and wrong predictions from compound testing.
doi:10.14573/altex1406111 fatcat:h2373gjoirg6hj2qv556jlliya