Albino rats were exposed to carburetor cleaners with varying routes of exposure using five treatments viz control group1, & groups 2, 3, 4 & 5 representing (inhalatory, feed incorporated, oral and dermal routes) respectively. Haematological parameters as; PCV, HB, RBC, McV, McH, and McHc were evaluated, while the semen analysis such as; Motility quantitative (M1), Debris quantitative (D1), sperm count (C), morphology primordial (Mp), and morphology structure (Ms) were determined. The results

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... ealed the following mean value of PCV for groups 1, 2, 3, 4, and 5 as 47.5, 40.0, 35.0, 20.5, and 23.25 respectively with significant differences (P<0.05) across the group, for HB 15.38, 14.25, 12.10, 8.30 and 8.78 for group 1, 2, 3, 4 and 5 respectively with significant difference (P<0.05) across the group. RBC and McV had a mean value of 5.27 and 9.08, 4.15and 9.59, 3.57 and 10.01, 2.33 and 8.77, 1.85 and 14.66 for groups 1, 2, 3, 4, and 5 respectively with significant differences (P<0.05) across the group. While McH and McHc had a mean value of 2.94 and 0.32, 3.42 and 0.36, 3.45 and 0.35, 3.59 and 0.41, 5.51 and 0.39 for groups 1, 2, 3, 4, and 5 respectively with significant difference (P<0.05) across the group. For semen analysis, M1 was 66.25, 52.5, 43.75, 31.25 and 23.75 for group 1, 2, 3, 4 and 5 respectively, Debris D1 was 6.25, 7.5, 8.75, 28.75 and 7.5 for group 1, 2, 3, 4 and 5 respectively, C and Mp were 53.25 and 6.25, 47.5 and 6.25, 42.0 and 17.75, 36.25 and 27.50, 37.25 and 30.0 for group 1, 2, 3, 4 and 5 respectively also. Finally, Ms was 1.0, 1.0, 1.25, 1.50 and 1.75 for group 1, 2, 3, 4 and 5 respectively. The results generally indicate that carburetor cleaner exerts a negative effect on the body irrespective of the route of exposure and extreme care should be taken when handling and utilization.