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RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma
2010
Molecular Cancer
Ewing's sarcomas are aggressive musculoskeletal tumors occurring most frequently in the long and flat bones as a solitary lesion mostly during the teen-age years of life. With current treatments, significant number of patients relapse and survival is poor for those with metastatic disease. As part of novel target discovery in Ewing's sarcoma, we applied RNAi mediated phenotypic profiling to identify kinase targets involved in growth and survival of Ewing's sarcoma cells. Results: Four Ewing's
doi:10.1186/1476-4598-9-218
pmid:20718987
pmcid:PMC2933621
fatcat:6ammfuxq5baz5otnel5s7z3lni