Efflux pump expression in MDR Acinetobacter baumannii strains from a tertiary care hospital in Lima, Peru [post]

Stefany Plasencia-Rebata, Saul Levy-Blitchtein, Isaac Peña-Tuesta, Miguel Angel Aguilar-Luis, William Vicente Taboada, Fernando Barreda Bolaños, Wilmer Silva-Caso, Juana del Valle Mendoza
2020 unpublished
Objetive: To analyze the contribution of the active efflux system to quinolones and aminoglycosides resistance in selected outbreak A. baumannii clinical isolates using the efflux pump inhibitor PAβN.Results: A total of nineteen Acinetobacter baumannii strains were included in the study. All were positive for the blaOXA-51 gene by PCR and had clinical information associated. The samples were non-duplicate and collected from different sources. Non-susceptibility rates were as following:
more » ... following: tobramycin 31.6% (6), ciprofloxacin 31.6% (6), levofloxacin 21.1% (4), nalidixic acid 26.3% (5) and amikacin 15.8% (3). A total of eight strains (42,1%) demonstrated an increase in the susceptibility rates and sixteen (84,2%) expressed efflux pumps.
doi:10.21203/rs.3.rs-25924/v1 fatcat:4efp77vmkfg5rdgkayqyd5emra