Purpose: The purpose of our work is to propose a strategic model of smart specialization identification around the concept of regional knowledge and cognitive transfer (Double Helix Matrix, DHM). Design/Methodology/Approach: While operationalization of smart specialization-oriented policy is still rather limited because of the lack of agreed development policy tools, we proposed the DHM model developed in order to provide the implementation of regional smart specialization oriented strategy.

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... model has been statistically verified by multidimensional comparative analysis on the example of a chosen weak innovative emerging region in Poland (Opolskie). Findings: The proposed methodology let us to find the need of redefining the smart specialization concept as a part of regional innovation strategy. Practical Implications: The new approach to the regional innovation policy has been proposed.. The findings have been used to construct the regional policy directives for potential smart specializations development within 2027 perspective. Originality/Value: The new model to conduct regional innovation strategy for smart specialization has been proposed and verified on the example of the weak innovation region.