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Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints
Journal of Biological Chemistry
Chromosomal translocations and deletions are among the major events that initiate neoplasia. For lymphoid chromosomal translocations, misrecognition by the RAG (recombination activating gene) complex of V(D)J recombination is one contributing factor that has long been proposed. The chromosomal translocations involving LMO2 (t(11;14)(p13;q11)), Ttg-1 (t(11;14)(p15;q11)), and Hox11 (t(10;14)(q24;q11)) are among the clearest examples in which it appears that a D or J segment has synapsed with andoi:10.1074/jbc.m103797200 pmid:11390401 fatcat:izpogoi4gvcv5ecaqxyphmw5i4