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Oxidant-induced arachidonic acid release and impairment of fatty acid acylation in vascular smooth muscle cells
1998
American Journal of Physiology
Oxidative damage, which plays a major role in the early stages of atherosclerosis, is associated with arachidonic acid (AA) release in vascular smooth muscle cells (VSMC) as in other cell types. In this study, H2O2 was used to investigate mechanisms of AA release from VSMC on oxidative stress. Cell treatment with H2O2 inhibited AA incorporation in an inverse relationship to prolonged H2O2-induced AA release. Identical kinetics of inhibition of AA incorporation and AA release were observed after
pmid:9575801
fatcat:2lomoxoq7jgidlf3bzjnmssehy