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Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors
Drs Saak Victor Ovsepian and Lidia Blazques-Llorca contributed equally to this work. Abstract Synaptic dysfunctions and altered neuronal activity play major role in the pathophysiology of Alzheimer's disease (AD), with underlying mechanisms largely unknown. We report that in the prefrontal cortex of amyloid precursor proteinpresenilin 1 and APP23 AD mice, baseline activity of pyramidal cells is disrupted by episodes of paroxysmal hyperactivity. Induced by spontaneous EPSC bursts, thesedoi:10.1093/cercor/bhw267 pmid:27600841 fatcat:zx7yrbaew5agtjcznlym4nbfvi