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We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of b-cell functionadjustment for insulin resistance using the disposition index. Multivariate analysis showed that HMW adiponectin was significantly and inverselydoi:10.1111/jdi.12821 pmid:29451743 fatcat:n27j6fomjjeorgj57zxu6zkb64