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We developed a three-wavelength time-resolved spectroscopy ͑TRS͒ system, which allows quantitative measurement of hemodynamics within relatively large living tissue. We clinically evaluated this TRS system by monitoring cerebral circulation during cardiopulmonary bypass surgery. Oxyhemoglobin, deoxyhemoglobin, total hemoglobin and oxygen saturation ͑SO 2 ͒ were determined by TRS on the left forehead attached with an optode spacing of 4 cm. We also simultaneously monitored jugular venous oxygendoi:10.1117/1.2804931 pmid:18163815 fatcat:lr5daiqhbzbntgw376lrkebynm