Clinical evaluation of time-resolved spectroscopy by measuring cerebral hemodynamics during cardiopulmonary bypass surgery

Etsuko Ohmae, Motoki Oda, Toshihiko Suzuki, Yutaka Yamashita, Yasuyuki Kakihana, Akira Matsunaga, Yuichi Kanmura, Mamoru Tamura
2007 Journal of Biomedical Optics  
We developed a three-wavelength time-resolved spectroscopy ͑TRS͒ system, which allows quantitative measurement of hemodynamics within relatively large living tissue. We clinically evaluated this TRS system by monitoring cerebral circulation during cardiopulmonary bypass surgery. Oxyhemoglobin, deoxyhemoglobin, total hemoglobin and oxygen saturation ͑SO 2 ͒ were determined by TRS on the left forehead attached with an optode spacing of 4 cm. We also simultaneously monitored jugular venous oxygen
more » ... aturation ͑SjvO 2 ͒ and arterial blood hematocrit ͑Hct͒ using conventional methods. The validity and usefulness of the TRS system were assessed by comparing parameters obtained with the TRS and conventional methods. Although the changes in SO 2 were lower than those in SjvO 2 , SO 2 obtained by TRS paralleled the fluctuations in SjvO 2 , and a good correlation between these values was observed. The only exceptions occurred during the perfusion period. Moreover, there was a good correlation between tHb and Hct values ͑r 2 = 0.63͒. We concluded that time-resolved spectroscopy reflected the conditions of cerebral hemodynamics of patients during surgical operations.
doi:10.1117/1.2804931 pmid:18163815 fatcat:lr5daiqhbzbntgw376lrkebynm