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Safe dose of intravitreal imatinib and its effect on laser-induced choroidal neovascularization: a rat-model experiment
2015
International Journal of Retina and Vitreous
This two-phase experimental study was conducted to determine the maximum safe dose of intravitreal imatinib (IVI) and its inhibitory effect on a rat model of choroidal neovascularization (CNV). Methods: In phase I, 60 rats were divided into six groups (A to F); five of which received IVI with concentrations of 330 (A), 250 (B), 165 (C), 80 (D), and 40 (E) µg/5 µl, and the control group (F) received balanced salt solution (BSS). In addition to electroretinography (ERG), routine histopathological
doi:10.1186/s40942-015-0017-4
pmid:27847609
pmcid:PMC5088484
fatcat:3txrlgicpnbqpjol5hf7szpo4u