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High-throughput automated microfluidic sample preparation for accurate microbial genomics
2017
Nature Communications
Low-cost shotgun DNA sequencing is transforming the microbial sciences. Sequencing instruments are so effective that sample preparation is now the key limiting factor. Here, we introduce a microfluidic sample preparation platform that integrates the key steps in cells to sequence library sample preparation for up to 96 samples and reduces DNA input requirements 100-fold while maintaining or improving data quality. The general-purpose microarchitecture we demonstrate supports workflows with
doi:10.1038/ncomms13919
pmid:28128213
pmcid:PMC5290157
fatcat:4psfqq6h6nccpmjzg73plfcnty