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The b-barrel outer membrane proteins constitute one of the two known structural classes of membrane proteins. Whereas there are several different webbased predictors for a-helical membrane proteins, currently there is no freely available prediction method for b-barrel membrane proteins, at least with an acceptable level of accuracy. We present here a web server (PRED-TMBB, http://bioinformatics. biol.uoa.gr/PRED-TMBB) which is capable of predicting the transmembrane strands and the topology ofdoi:10.1093/nar/gkh417 pmid:15215419 pmcid:PMC441555 fatcat:roej5xoq6nee3adfbb273c75tu