T-cell cytokine responses in human infection with Mycobacterium tuberculosis

M Zhang, Y Lin, D V Iyer, J Gong, J S Abrams, P F Barnes
1995 Infection and Immunity  
Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4 ؉ cells. At the level of systemic T cells, development of tuberculosis is associated with
more » ... is associated with diminished Th1 but not enhanced Th2 responses.
doi:10.1128/iai.63.8.3231-3234.1995 fatcat:burufo3tfreonp46mka54alxfq