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Influenza A viruses are negative-strand RNA viruses. The gene of hemagglutinin (HA) protein in the virus genome is the major molecule that determining the range of hosts. Mutation of HA gene may bring infection cross species. In this paper, we studied physicochemical constraints during the variations of HA gene. Fuzzy measure and Choquet integral were used to estimate the combining effect of different physicochemical properties for single residue in HA protein that related to infective events.doi:10.1109/icnc.2008.712 dblp:conf/icnc/ChangSWLLL08 fatcat:pdtzpb6rxjbqvgygej46mw5szi