A case of pulmonary alveolar proteinosis with interstitial fibrosis and emphysematous bulla

Masahito Kato, Hirohiko Nagasaka, Kazuhide Yamamoto, Akihiko Takeshima, Shigeru Arai, Michihiko Aoyama, Kunio Nanjo, Joichi Kato, Kazuo Yoshitomo, Toshihiko Takeuchi, Yukio Goto, Takako Tuda (+1 others)
1985 The Japanese Journal of Thoracic Diseases  
of Medicine A 19 year-old man with pulmonary alveolar proteinosis was admitted to our hospital. Pulmonary lavage was performed 9 times for two years because of repeated and worsening symptoms. The chest film on admission showed bilateral pulmonary infiltrates with micronodular dissemination and multicystic shadows in the left lower lung filed, but with the lapse of time the chest films revealed a slow increase in multicystic shadows of various size throughout bilateral lung fields. Then the
more » ... ent suffered from bilateral pneumothoraces and died of respiratory failure. At autopsy, macroscopic findings of the lungs revealed consolidation in the interior part and many cysts of venous sizes in the subpleural area. Histologically much amorphus material filled in alveoli with or without thickened alveolar walls and many cysts might be considered emphysematous bulla or bronchioloectasis due to lung fibrosis.
doi:10.11389/jjrs1963.23.928 fatcat:3v63nfs54zb25pld4usmutcsye