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kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents
Vagal reflexes regulate homeostasis in visceral organs and systems through afferent and efferent neurons and nerve fibers. Small, unmyelinated, C-type afferents comprise over 80% of fibers in the vagus and form the sensory arc of autonomic reflexes of the gut, lungs, heart and vessels and the immune system. Selective bioelectronic activation of C-afferents could be used to mechanistically study and treat diseases of peripheral organs in which vagal reflexes are involved, but it has not beendoi:10.1016/j.brs.2022.09.015 pmid:36241025 fatcat:qbvaauaqevfjjpwz5a4tdwvwgq