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P Using Polyethylene Glycol Precipitation to Differentiate between Macroprolactinemia and Hyperprolactinemia
Siriraj Med J
Hyperprolactinemia is a common endocrine disorder which clinically manifestats in reproductive period and presents with hypogonadism, galactorrhea and symptoms related to tumor mass effects. Hyperprolactinemia is a state of excess total prolactin (PRL) concentration in serum. Three forms of PRL in sera are monomeric PRL with 23 kilo-dalton (kDa) MW which acts bioactively which is predominant in patients with prolactinomas, dimeric PRL; 45-60 kDa MW which is not clearly bioactive andfatcat:ztfxtzho7fdf7ezowf4x2qn3ha