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Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans
2011
Molecular Psychiatry
Opioid neurotransmission has a key role in mediating reward-related behaviours. Opioid receptor (OR) antagonists, such as naltrexone (NTX), can attenuate the behaviour-reinforcing effects of primary (food) and secondary rewards. GSK1521498 is a novel OR ligand, which behaves as an inverse agonist at the l-OR sub-type. In a sample of healthy volunteers, we used [ 11 C]-carfentanil positron emission tomography to measure the OR occupancy and functional magnetic resonance imaging (fMRI) to measure
doi:10.1038/mp.2011.29
pmid:21502953
pmcid:PMC3142667
fatcat:4qov4xiomjdcxjrpaagxgr6y3y