Objective: Bisphenol A [BPA] has been using throughout the world for years and makes a contribution to endocrine disruptor by oxidative stress induction in ovarian tissue. This study aimed to determine the effects of Ginger extract [GE], as an efficient antioxidant, on ovarian tissue in BPA-treated mice. Materials and Methods : adult female mice were divided into 4 groups [n=6]: control, BPA [240mg/kg/day], GE [500 mg/kg/day] and BPA+GE. Oral treatment of GE was performed during 30 days. After

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... reatments, to histological evaluation, ovaries were removed and processed. Serum MDA levels were also determined by the spectrophotometric method. Data were analyzed with One Way ANOVA test and P<0.05 was considered as statistically significant. Results: The total volume of the ovary, cortex, medulla, Corpus luteum and the mean number of primordial, primary, preantral and antral follicles significantly decreased in the BPA groups compared with the control group [p<0.001]. A significant decrease in the volume of oocyte and its nuclei in the different types of follicles and also thickness of zona pellucida in preantral and antral follicles were observed in BPA group compared to control group [p<0.001]. Serum malondialdehyde [MDA] levels significantly increased in the BPA group compared with the control group [p<0.001]. Co-administration of GE and BPA compensated for the adverse effects of BPA on the above parameters. Furthermore, the mean number of different types of follicles significantly increased in GE-treated mice compared to the control group [p<0.001].