Immunohistochemical Expression of Platelet Growth Factor and Vascular Endothelial Growth Factor in Patients With Melanoma With and Without Redness (Brenner Sign)

Jacob Mashiah, Yonit Wohl, Yoav Barnea, Shlomo Schneebaum, Andrea Gat, Faina Misonzhnik-Bedny, Sarah Brenner
2007 Archives of Dermatology  
Objective: To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both. Methods: Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor.
more » ... ll growth factor. Results: Vascular endothelial growth factor was positive in 3 of 6 patients (50%) with melanoma and red-ness (Brenner sign) and in 4 of 7 patients (57%) with melanoma without redness. Platelet-derived endothelial cell growth factor was positive in all 6 patients (100%) with melanoma and redness and in 4 of 7 patients (57%) with melanoma without redness. Conclusion: Platelet-derived endothelial cell growth factor may have a part in the pathogenesis of the redness observed in patients with melanoma, called Brenner sign, by affecting vasculature function.
doi:10.1001/archderm.143.8.1001 pmid:17709658 fatcat:aoloyrez45emplmlnftryxsgoy