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Respiratory adverse events are not uncommon in the post anesthesia care unit (PACU) following general anesthesia. In this regard, hyperventilation leading to apnea and desaturation is a rare entity. Here we have reported a case of a 15 year old girl who, following an uneventful general anesthesia, developed severe hyperventilation leading to apnea and desaturation in the PACU. Case presentation The 15 year old girl underwent cortical mastoidectomy under general anesthesia. After a smoothdoi:10.21203/rs.2.518/v1 fatcat:ban4ub4bwnevbak7lj36blbrgq