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Spectrofluorimetry experiments using synthetic trisaccharides indicate that in compounds that display affinity for antithrombin El (AT-III), a unique trisaccharide sequence plays the key role in the eariy recognition, and the first step of AT-IU activation. Added to previous observations, these new results suggest that the two-step binding mechanism previously proposed (Olson et al, J. BioL Chem., 1981,256, 11073-11079) might involve, in the first place, a confonnational change of the protein,doi:10.1093/glycob/7.3.323-e pmid:9147040 fatcat:6kmutvzsyjhwfhrz36efoxzk7q